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目的:探讨上消化道出血采用奥曲肽、奥美拉唑单用与联合应用疗效比较的临床研究。方法:将我院消化内科2015年2月至2017年2月收治的上消化道出血病患120例作为研究对象,按入院先后顺序随机分为三组,就奥美拉唑单用治疗(A组,n=40)、奥曲肽单用治疗(B组,n=40)与两种药物联用治疗(C组,n=40)三组之间展开疗效对比研究。结果:A组总有效率为81.5%,高于B组66.7%,但C组总有效率为97.1%,均较高于A组及B组,临床有统计学差异(P<0.05)。而且C组在平均呕血停止时间及平均黑便停止时间上,均明显短于A组及B组,临床有统计学差异(P<0.05)。结论:奥美拉唑联合奥曲肽治疗上消化道出血较单药应用止血疗效显著,可缩短止血时间,值得临床推广应用。
Objective: To investigate the clinical efficacy of octreotide and omeprazole alone or in combination with topical gastrointestinal bleeding in upper gastrointestinal bleeding. Methods: A total of 120 patients with upper gastrointestinal bleeding who were admitted to our hospital from February 2015 to February 2017 were enrolled in this study. Patients were randomly divided into three groups according to the sequence of hospital admission. The patients were treated with omeprazole alone (A (N = 40, n = 40). The efficacy of octreotide alone (group B, n = 40) was compared with that of the two drugs (group C, n = 40). Results: The total effective rate in group A was 81.5%, higher than that in group B 66.7%, but the total effective rate in group C was 97.1%, which was higher than that in group A and group B (P <0.05). Moreover, the average vomiting blood stop time and average black stool stop time in group C were significantly shorter than those in group A and group B, with statistically significant difference (P <0.05). Conclusion: Omeprazole combined with octreotide in the treatment of upper gastrointestinal bleeding than single application of hemostasis curative effect is significant, can shorten the time to stop bleeding, worthy of clinical application.