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目的 了解前列腺素 E1 (PGE1 )对慢性肾功不全(CRF)失代偿期患者肾动脉血流动力学的影响 .方法 利用彩色多普勒观察 5 0例 CRF失代偿期患者经 PGE1 治疗前、后的肾动脉血流动力学的变化 .结果 CRF失代偿期患者肾动脉血流动力学的各项参数 ,特别是肾动脉内径 (D)、时间速度积分 (VTI)、阻力指数 (RI)变化显著 (P<0 .0 1) ;PGE1 治疗后 ,其各项参数均有明显的变化 (P<0 .0 5 ) ;同时 BU N,Cr水平由治疗前的 (15 .14± 5 .37) mmol· L- 1 ,(193.6 1±5 1.35 )μmol· L- 1 降至 (7.89± 6 .0 4) mmol· L- 1 ,(98.99±35 .17)μmol· L- 1 ,尿量由 (948.3± 12 7.7) m L· d- 1 增至(12 41.6± 372 .9) m L· d- 1 ,均有明显的改善 (P<0 .0 5 ) .结论 CRF失代偿期时多伴有凝血、纤溶障碍所导致的肾动脉血流动力学变化 ,用 PGE1 治疗有益于延缓肾功能的恶化
Objective To investigate the effect of prostaglandin E1 (PGE1) on renal arterial hemodynamics in patients with decompensated chronic renal failure (CRF) .Methods Fifty patients with CRF decompensated by color Doppler were examined before PGE1 treatment , Respectively.Results The parameters of renal artery hemodynamics in patients with CRF decompensation, especially the diameter of renal artery (D), time-velocity integral (VTI) and resistance index (RI) (P <0.01). After treatment with PGE1, there were significant changes in various parameters (P <0.05). At the same time, the levels of BU N and Cr were significantly different from those before treatment (15.14 ± 5 (37.3 mmol·L -1), (37.6 mmol·L -1), (37.6 mmol·L -1) The urinary output increased significantly from (948.3 ± 12.77) m L · d-1 to (12 41.6 ± 372.9) m L · d-1, with significant improvement (P0.05) When the pay is often accompanied by coagulation, fibrinolytic renal artery caused by hemodynamic changes, treatment with PGE1 beneficial to delay the deterioration of renal function