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目的：探讨广州地区人群乳头状瘤病毒（HPV）的流行情况和感染亚型分布情况。方法采用HPV21分型试剂对7252例患者进行HPV分型检测。结果在7252例研究对象中，21种HPV亚型均被检测出，阳性率35.5%，感染频率由高到低的前10位HPV亚型依次是HPV16、52、58、53、cp8304、18、33、39、11、31。结论在广州地区最常见的HPV亚型是HPV16、52、58，导流杂交基因分型技术能够同时检测高危、低危和其他HPV亚型，可判断多重感染，用于临床诊断和普查均为理想方法。“,”Objective Discusses human papil omavirus (HPV) genotypes distribution of prevalence and infection in guangzhou. Methods 7252 samples were measured by the gene-chip. Results 21 HPV genotypes have been detected in 7252 samples. Infection from high to low frequency of the top 10 in turn are HPV16、52、58、53、cp8304、18、33、39、11、31. Conclusion The most common HPV genotypes are HPV16, 52, 58 in guangzhou area. gene-chip can simultaneously detect high-risk and low-risk HPV genotypes, and other can determine multiple infections, are ideal for clinical diagnosis and census method.