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目的探讨肿瘤复发患者化疗前后血清中C-反应蛋白(CRP)的变化情况。方法选取36例做化疗的肿瘤复发患者,利用散射免疫比浊法定量测定患者血清中的CRP值,比较其在化疗前后血清中CRP的变化,并进行分析。结果 36例肿瘤复发患者化疗前的CRP检测发现,30例呈阳性,6例呈阴性,并且有19例化疗有效,17例化疗最终无效。化疗有效者的CRP与化疗前相比显著下降,差异有统计学意义,而化疗无效者血清中的CRP比化疗前升高,差异有统计学意义。结论肿瘤复发患者进行化疗的疗效与血清中的CRP变化呈负相关,化疗后CRP升高预示着预后效果不好。CRP可作为肿瘤复发患者化疗疗效的参考指标。
Objective To investigate the changes of serum C-reactive protein (CRP) in patients with tumor recurrence before and after chemotherapy. Methods Thirty-six patients with tumor recurrence who were treated with chemotherapy were enrolled in this study. The serum CRP level was measured by the method of nephelometry. The changes of serum CRP level before and after chemotherapy were compared and analyzed. Results 36 patients with tumor recurrence before chemotherapy CRP test found that 30 cases were positive, 6 cases were negative, and 19 cases of chemotherapy, 17 cases of chemotherapy eventually invalid. The CRP of chemotherapy-effective patients decreased significantly compared with that before chemotherapy, with significant difference, while the serum CRP levels of chemotherapy-ineffective patients were significantly higher than those before chemotherapy, with significant difference. Conclusion The efficacy of chemotherapy in patients with tumor recurrence is negatively correlated with the changes of CRP in serum. The elevated CRP after chemotherapy indicates that the prognosis is not good. CRP can be used as a reference for the efficacy of chemotherapy in patients with tumor recurrence.