Rheumatoid arthritis (RA) is characterized by joint leukocyte infiltration,synovial inflammation and bone damage result from osteoclastogenesis.Bruton\'s tyrosine kinase (BTK) is a key regulator of B cell receptor (BCR) and Fc gamma receptor (FcγR) sign
COVID-19 is a multiorgan systemic inflammatory disease caused by SARS-CoV-2 virus.Patients with COVID-19 often exhibit cardiac dysfunction and myocardial injury,but imaging evidence is lacking.In the study we detected and evaluated the severity of myocard
Lung cancer is one of the leading causes of cancer-related death worldwide.Various therapeutic failed in the effective treatment of the lung cancer due to their limited accumulation and exposure in tumors.In order to promote the chemotherapeutics delivery
B cell activating factor of TNF family (BAFF) is a member of TNF ligand superfamily and plays a key role in B cell homeostasis,proliferation,maturation,and survival.In this study,we detected BAFF level,the expressions of BAFF receptors and important molec
Chemotherapy-related fatigue (CRF) is increasingly being recognized as one of the severe symptoms in patients undergoing chemotherapy,which not only largely reduces the quality of life in patients,but also diminishes their physical and social function.At
Antiepileptic drug zonisamide has been shown to be curative for Parkinson\'s disease (PD) through increasing HMG-CoA reductase degradation protein 1 (Hrd1) level and mitigating endoplasmic reticulum (ER) stress.Hrd1 is an ER-transmembrane E3 ubiquitin l
目的 探讨幼儿入园焦虑与母亲人格特质及焦虑水平的关系.方法 通过“幼儿园”和“第一次”作为关键词,搜索到约90万条新浪微博.根据人工筛选获得的幼儿母亲所发布的768条微博.参考《精神障碍诊断与统计手册》第5版(DSM-5)的分离焦虑障碍诊断标准评估幼儿入园焦虑程度,利用“文心”中文心理分析系统(TextMind)分析母亲的人格特质和母亲在幼儿入园前后的焦虑水平.结果 幼儿入园焦虑程度与母亲在幼儿入园前1个月、入园后1个月和3个月的焦虑水平呈正相关,与母亲的外向性和开放性呈负相关,与母亲的神经质无显著相关关
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum (ER) stress and oxidative stress to impair endothelial function.The glucagon-like
针对神经外科学教学中存在的问题,为提高教学质量,对临床教学进行整合改革.运用整合医学(HIM)理念,调整教学计划,建立有利于临床诊疗思维能力、创新精神培养和综合素质提高的HIM教学体系.运用整合教学方式后,有效地提高了神经外科的临床教学质量,学生不仅具备了一定的专业知识和较强的临床能力,而且学习兴趣明显增强.因此,将HIM理念贯穿于神经外科临床教学,对医学生临床思维的培养和手术技巧进步具有重要意义,特别是能够加快年轻医生的成长,对于专培医生效果更加显著.
Zinc finger E-box-binding homeobox 1 (ZEB1),a functional protein of zinc finger family,was aberrant expressed in many kinds of liver disease including hepatic fibrosis and Hepatitis C virus.Bioinformatics results showed that ZEB1 was abnormally expressed