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本工作对富勒烯进行修饰,将cyclen连接在富勒烯上,成功合成了一种潜在的促排化合物——多取代富勒烯大环多胺衍生物(CB),运用改良寇氏法得到了化合物的半致死剂量,在完成其毒性实验的基础上,建立了染铀的小鼠模型,探究该化合物对小鼠体内铀的促排效果。结果表明,多取代富勒烯大环多胺衍生物的半致死剂量为1.767 mg;CB进入小鼠体内并不会改变铀在小鼠体内的分布规律;与二乙基三胺五乙酸(DTPA)阳性对照组和空白组相比,CB对小鼠肝脏和骨骼中的铀有较明显的促排效果。CB可作为一种潜在的铀促排化合物。
In this work, fullerene was modified to connect cyclen to fullerenes, and a potential compound for accelerating the production of multi-substituted fullerene macrocyclic polyamine derivatives (CB) was successfully synthesized. The modified Kovar method The semi-lethal dose of the compound was obtained. Based on the completion of its toxicity test, a mouse model of uranium was established to explore the effect of the compound on uranium in mice. The results showed that the semi-lethal dose of multi-substituted fullerene macrocyclic polyamine derivatives was 1.767 mg. The distribution of uranium in mice did not change when CB was injected into mice. Compared with diethylenetriaminepentaacetic acid (DTPA) ) Positive control group compared with the blank group, CB on mouse liver and bone uranium has a more significant effect of promoting the emission. CB can be used as a potential uranium promoting compounds.