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目的观察血管紧张素转换酶抑制剂(ACEI)卡托普利和醛固酮拮抗剂螺内酯治疗心力衰竭的有效性和安全性。方法25例心力衰竭患者为治疗组,联合服用卡托普利及螺内酯治疗;23例心力衰竭患者对照组予以卡托普利及速尿或双氢克尿噻治疗,经4～6周治疗后观察血压和心功能的改善情况。结果治疗组显效及有效23例,无效2例,总有效率92%。对照组显效及有效17例,无效6例,总有效率为73.9%。有效率之间的显著性差异采用χ2检验,P<0.05,两组比较差异有统计学意义。结论ACEI和醛固酮拮抗剂治疗心力衰竭是有效和安全的。
Objective To investigate the efficacy and safety of angiotensin converting enzyme inhibitor (ACEI) captopril and aldosterone antagonist spironolactone in the treatment of heart failure. Methods Twenty-five patients with heart failure were treated with captopril and spironolactone, and 23 patients with heart failure were treated with captopril and furosemide or hydrochlorothiazide. After 4 to 6 weeks of treatment, Observe the improvement of blood pressure and heart function. Results The treatment group was effective and effective in 23 cases, 2 cases were ineffective, the total effective rate was 92%. The control group was effective and effective in 17 cases, 6 cases were ineffective, the total effective rate was 73.9%. Significant differences between the effective rate using χ2 test, P <0.05, the difference between the two groups was statistically significant. Conclusion ACEI and aldosterone antagonists are effective and safe for the treatment of heart failure.