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血吸虫病的主要病理损害是虫卵肉芽肿,关于日本血吸虫卵肉芽肿的知识了解甚少。本文使用小鼠肺肉芽肿模型,观察肺内日本血吸虫卵肉芽肿形成的动力学与机理。方法实验鼠分8组(每组7～8只),分别皮下注射10～50,000个日本血吸虫卵致敏鼠,以不注射的鼠作对照。2周后再静注虫卵3,000个,其后在不同天数(1～64天)取肺作病理检查,每鼠至少检测30个肉芽肿面积,求其平均值作t检验。用2,000个虫卵致敏鼠后2周,将5,000个虫卵分别由门静脉注入肝或由尾静脉注入肺,8天后分别取肝及肺,测肉芽肿面积。分离肺内肉芽肿,并从肉
The main pathological lesion of schistosomiasis is an egg granuloma, little understood about the knowledge of Schistosoma japonicum egg granuloma. In this paper, the mouse lung granuloma model was used to observe the kinetics and mechanism of Schistosoma japonicum egg granuloma formation in the lung. Methods The experimental rats were divided into 8 groups (7-8 per group), and 10-50,000 mice were injected subcutaneously with Schistosoma japonicum eggs, respectively. The mice were injected with no injection. Two weeks later, the eggs were injected intravenously 3,000 daily. After that, lungs were taken for pathological examination on different days (1 ~ 64 days). At least 30 granulomas were detected in each rat. The mean value was used for t test. Two weeks after infecting mice with 2,000 eggs, 5,000 eggs were injected into the liver from the portal vein or into the lungs through the tail vein respectively. After 8 days, the liver and lungs were taken and the granuloma area was measured. Isolated intra-granuloma, and from the meat