目的:了解血必净注射液的循证应用及不良反应,为合理使用提供参考。方法:对中国知网2012年前发表的关于血必净注射液循证评价及不良反应的文献进行综述。结果:对血必净注射液在脓毒症、多器官功能障碍综合征、急性胰腺炎、肺部感染及急性呼吸窘迫综合征、慢性肺心病心力衰竭的应用进行了循证评价;不良反应发生率约为4.00%,以变态反应为主。结论:在常规治疗的基础上加用血必净注射液,能提高对以上疾病的治疗效果,但尚需进行更严谨的临床试验;并要加强对超说明书使用的管理;使用中要重视变态反应的发生。 Objective: To understand the evidence-based application of Xuebijing injection and its adverse reactions, to provide a reference for rational use. Methods: The literature about evidence-based evaluation of Xuebijing injection and adverse reactions published by CNKI before 2012 was reviewed. Results: The application of Xuebijing Injection in sepsis, multiple organ dysfunction syndrome, acute pancreatitis, pulmonary infection and acute respiratory distress syndrome, and chronic cor pulmonale heart failure were evidence-based evaluation; adverse reactions occurred Rate of about 4.00%, with allergy-based. Conclusion: The addition of Xuebijing injection on the basis of routine treatment can improve the treatment effect on the above diseases, but more rigorous clinical trials are still needed; the management of the use of super manuals should be strengthened; The reaction occurred.