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近来研究发现他汀类药具有免疫调节功能。临床及动物实验发现,他汀类药用于多发性硬化的治疗将会带来更多益处。动物实验证实,他汀类药即可抑制也可逆转慢性或缓解复发性实验性自身免疫性脑脊髓炎,临床上也有证据表明他汀类药在多发性硬化的治疗中是有益的。他汀类药的免疫调节作用是多方面的,包括:减少白细胞向中枢神经系统移动;抑制促炎症T细胞激活;减少T细胞介导的炎症介质的表达;减少炎症介质在中枢神经系统的表达。
Recent studies have found that statins have immunomodulatory function. Clinical and animal experiments have shown that statin therapy for multiple sclerosis will bring more benefits. Animal experiments confirmed that statin drugs can be inhibited can also reverse chronic or relieve relapsed experimental autoimmune encephalomyelitis, there is also evidence of statins statins in the treatment of multiple sclerosis is beneficial. The immunomodulatory effects of statins are manifold and include: reducing the movement of leukocytes to the central nervous system; inhibiting the activation of pro-inflammatory T cells; decreasing the expression of inflammatory mediators mediated by T cells; and decreasing the expression of inflammatory mediators in the central nervous system.