论文部分内容阅读
目的 分析肥胖儿童脂蛋白(a)[Lp(a)]、纤溶指标的变化及其相关性,探讨儿童期肥胖是否存在动脉粥样硬化的高危因素及脂代谢与血栓形成间的相互作用。方法 应用免疫比浊法检测60 例肥胖儿童及60 例正常体重健康儿童的血清Lp(a)、纤溶酶原(Pg)含量。以发色底物法测定血浆纤溶酶(Plm )的活性。以酶联免疫吸附双抗体夹心法(ELISA)检测血浆纤溶酶原激活抑制物-1(PAI-1)水平。结果 与正常对照组相比,肥胖儿童血循环Lp(a)、Pg、PAI-1 水平显著增加(P分别< 0.001,0.002,0.001),血浆Plm 活性显著降低(P< 0.02)。Lp(a)与Pg 和PAI-1 有显著正相关(r分别为0.950 和0.328 P< 0.001 和0.02)。Lp(a)和Plm 显著负相关(r= - 0.302 P< 0.02)。结论 肥胖儿童血脂增加、纤溶受抑,存在致动脉粥样硬化的高危因素。高水平Lp(a)与纤溶受抑密切相关
Objective To analyze the changes of lipoprotein (a) [Lp (a)] and fibrinolysis in obese children and to explore whether there is a risk factor for atherosclerosis in childhood obesity and the interaction between lipid metabolism and thrombosis. Methods The levels of Lp (a), plasminogen (Pg) in 60 obese children and 60 normal healthy children were detected by immunoturbidimetry. The activity of plasma plasmin (Plm) was measured by chromogenic substrate method. Plasma plasminogen activator inhibitor-1 (PAI-1) levels were measured by enzyme-linked immunosorbent assay (ELISA). Results The levels of Lp (a), Pg and PAI-1 in obese children significantly increased (P <0.001, 0.002 and 0.001 respectively) and plasma Plm activity decreased significantly compared with those in normal controls (P <0.02). There was a significant positive correlation between Lp (a) and Pg and PAI-1 (r = 0.950 and 0.328 P <0.001 and 0.02, respectively). There was a significant negative correlation between Lp (a) and Plm (r = - 0.302 P <0.02). Conclusion Obese children with increased blood lipids, fibrinolysis, there is a risk factor for atherosclerosis. High levels of Lp (a) and fibrinolysis are closely related