目的:探讨MRP-1/CD9和cyclinD1的表达与膀胱尿路上皮癌生物学行为的关系。方法:应用免疫组化法检测80例膀胱尿路上皮癌组织和12例正常对照组膀胱组织MRP-1/CD9和cyclinD1的表达情况。结果:MRP-1/CD9阳性表达率膀胱癌组为51.25%,对照组为91.11%(P<0.05);Ta～T1肿瘤阳性表达率为71.42%,T2～T4为35.56%;G1肿瘤阳性表达率为78.57%,G2为43.48%,G3为31.03%,随着肿瘤浸润性和分级上升,阳性表达率逐渐下降(P<0.01,P<0.05);MRP-1/CD9阳性表达率肿瘤初发和复发者之间差异无统计学意义(P>0.05);肿瘤单发者高于多发者(P<0.05)。膀胱尿路上皮癌cyclinD1阳性表达率为53.75%,对照组为0(P<0.01);Ta～T1肿瘤阳性表达率为78.57%,T2～T4为17.65%;G1肿瘤阳性表达率为85.71%,G2为56.52%,G3为20.69%,随着肿瘤浸润性和分级升高,cyclinD1阳性表达率逐渐降低(P<0.05,P<0.05)。cyclinD1阳性表达率肿瘤初发和复发者、多发者和单发者之间差异无统计学意义(P>0.05,P>0.05)。结论:MRP-1/CD9表达与膀胱尿路上皮癌的浸润性和分级相关,其表达缺失可能是判断该肿瘤预后的一个指标;cy-clinD1较能准确地评估膀胱尿路上皮癌的生物学行为,二者对于判断膀胱癌的预后有重要的临床意义 Objective: To investigate the relationship between the expression of MRP-1 / CD9 and cyclinD1 and the biological behavior of bladder urothelial carcinoma. Methods: The expression of MRP-1 / CD9 and cyclinD1 in bladder tissues of 80 cases of bladder urothelial carcinoma and 12 cases of normal control group were detected by immunohistochemistry. Results: The positive expression rates of MRP-1 / CD9 in bladder cancer group were 51.25% and 91.11% (P <0.05) respectively. The positive expression rate of Ta ~ T1 tumor was 71.42% and T2 ~ T4 was 35.56% The positive rate of MRP-1 / CD9 positive rate was 78.57%, G2 was 43.48%, G3 was 31.03%. The positive rate of MRP-1 / CD9 positive rate was gradually decreased with tumor invasiveness and grading (P <0.01, There were no significant differences between the two groups (P> 0.05). The positive expression rate of cyclinD1 in bladder urothelial carcinoma was 53.75%, and that in the control group was 0 (P <0.01). The positive expression rate of Ta ~ T1 was 78.57% and that of T2 ~ T4 was 17.65% G2 was 56.52% and G3 was 20.69%. The positive rate of cyclinD1 gradually decreased with tumor invasiveness and grading (P <0.05, P <0.05). The positive rate of cyclinD1 expression in primary tumor and relapse, multiple and single difference was not statistically significant (P> 0.05, P> 0.05). Conclusions: The expression of MRP-1 / CD9 is correlated with the invasiveness and grading of bladder urothelial carcinoma. The loss of expression of MRP-1 / CD9 may be an indicator of the prognosis of the tumor. Cy-clinD1 is more accurate in assessing the biology of bladder urothelial carcinoma Behavior, both for the judgment of the prognosis of bladder cancer has important clinical significance