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作者报告3例有10余年痤疮史患者,曾用数种抗生素治疗,效果不好,口服13-顺维甲酸后引起急性跟腱炎。例1为23岁男性患者,双侧跟腱急性疼痛,负重困难,行走时加重。上述症状出现于服用13-顺维甲酸1mg/kg 的6周后。体检:双侧跟腱肿胀、红斑、触痛,给布洛芬400mg每日3次无效。停用13-顺维甲酸后2周,症状几乎完全消失。再次给予13-顺维甲酸0.5mg/kg,跟腱炎复发,但其程度较轻,给予布洛芬400mg,每日3次可控制跟腱炎。故仍继续小剂量13-顺维甲酸治疗痤疮20周,停止治疗后2周,跟腱炎症状完全消失。
The authors report 3 patients who had more than 10 years of history of acne who had been treated with several antibiotics and were ineffective, causing acute Achilles tendinitis after oral administration of 13-cis-retinoic acid. Example 1: A 23-year-old male patient with acute bilateral Achilles tendon pain and difficulty in weight bearing. The above symptoms occurred 6 weeks after taking 1 mg / kg of 13-cis-retinoic acid. Physical examination: bilateral Achilles tendon swelling, erythema, tenderness, to ibuprofen 400mg 3 times a day is invalid. Two weeks after discontinuation of 13-cis retinoic acid, the symptoms almost completely disappeared. Again give 13-cis retinoic acid 0.5mg / kg, recurrence of Achilles tendinitis, but to a lesser extent, given ibuprofen 400mg, 3 times a day to control Achilles tendinitis. Therefore, the small dose of 13-cis-retinoic acid is still being treated for 20 weeks. After stopping the treatment for 2 weeks, the symptoms of Achilles tendon disappear completely.