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目的:了解2008年8月-2009年6月杭州儿童手足口病肠道病毒感染情况。方法:采用ELISA方法对464例儿童手足口病血清分别进行埃可病毒IgM、肠病毒IgM、柯萨奇病毒IgM、EV71IgM检测。结果:464例手足口病患儿中埃可病毒IgM检出率为71.7%(333/464),肠病毒IgM检出率为66.8%(310/464),柯萨奇病毒IgM检出率为59.3%(275/464),EV71IgM检出率为8%(37/464)。其中四种病毒中2种病毒同时感染的共55例,3种病毒同时感染的共227例(其中以柯萨奇病毒、埃可病毒、肠病毒同时感染居多,共222例),4种病毒同时感染的有26例。结论:埃可病毒是引起本次儿童手足口病流行的主要病原体。患儿体内存在不同肠道病毒的混合感染。
Objective: To understand the incidence of hand, foot and mouth disease (enterovirus) infection in Hangzhou children from August 2008 to June 2009. Methods: Serum samples of 464 children with hand, foot and mouth disease were detected by ELISA using IgM, IgM, Coxsackie’s IgM and EV71 IgG. Results: The IgM detection rate was 71.7% (333/464) in 464 cases of HFMD and 66.8% (310/464) in enterovirus. The detection rate of IgM in coxsackievirus A 59.3% (275/464), EV71IgM detection rate was 8% (37/464). Of the four viruses, 55 were simultaneously infected with 2 viruses and 227 were simultaneously infected with 3 viruses (of which, Coxsackie, Erkovirus and Enterovirus were most simultaneously infected at the same time, a total of 222), 4 viruses At the same time there are 26 cases of infection. Conclusion: Erkovirus is the major causative agent of hand, foot and mouth disease in children. Children with different intestinal virus mixed infection.