论文部分内容阅读
目的:探讨丹红注射液对UAP患者血清中MMPs、CK-MB和OX-LDL的影响。方法:将2013年7月-2014年6月在本科室就诊的63例不稳定型心绞痛患者纳入本研究。受试者的年龄在60~82周岁之间,平均(70.4±6.5)岁。将所有纳入的受试者按照性别区域化随机分为2组,分别为对照组(常规的抗冠心病UAP治疗,n=31)和丹红注射液组(在常规治疗方案的基础上每日静脉滴注丹红注射液30 mL,连续14 d,n=32)。采用酶联免疫吸附法测定血清中的MMP-2、MMP-9、CKMB以及OX-LDL水平,并考察心绞痛发作次数和发作持续时间以及心绞痛发作次数与以上血清指标的相关性。结果:本试验纳入的63例患者均无脱落,两组纳入患者的性别[χ2(1)=0.013,P=0.91>0.05]、BMI(P=0.319>0.05)以及年龄(P=0.121>0.05)均未呈现统计学差异。与对照组相比,丹红注射液组患者血清中的MMP-2(P=1.16×10~(-4))、MMP-9(P=4.74×10~(-4))、CK-MB(P=1.31×10~(-3))和OX-LDL(P=2.08×10~(-3))均显著降低,每周心绞痛的发作次数明显减少(P=1.93×10~(-7)),心绞痛的持续时间虽有缩短的趋势,但是无统计学上的差异(P=0.09>0.05)。心绞痛发作次数与以上血清指标显著正性相关。结论:丹红注射液可以显著降低不稳定型心绞痛患者冠状动脉粥样硬化斑块破裂的风险,保护心肌细胞、并在一定程度上缓解冠脉的血管炎性反应。
Objective: To investigate the effect of Danhong injection on serum MMPs, CK-MB and OX-LDL in UAP patients. Methods: Sixty-three patients with unstable angina who were admitted to our department from July 2013 to June 2014 were enrolled in this study. Subjects aged 60 to 82 years of age, with an average (70.4 ± 6.5) years. All the included subjects were randomly divided into two groups according to gender regionalization: control group (conventional anti-coronary heart disease UAP treatment, n = 31) and Danhong injection group (on the basis of routine treatment plan, daily Intravenous infusion of Danhong injection 30 mL, continuous 14 d, n = 32). Serum levels of MMP-2, MMP-9, CKMB and OX-LDL were measured by enzyme-linked immunosorbent assay. The correlation between the number of angina attacks and the duration of seizures, the number of angina attacks and the above serum indexes were also investigated. Results: Sixty-three patients were excluded from the study. There were no significant differences between the two groups in terms of sex (χ2 (1) = 0.013, P = 0.91> 0.05], BMI (P = 0.319> 0.05), and age ) Showed no statistical difference. Compared with the control group, serum MMP-2 (P = 1.16 × 10 -4), MMP-9 (P = 4.74 × 10 -4), CK-MB (P = 1.31 × 10 -3) and OX-LDL (P = 2.08 × 10 -3), the number of episodes of angina pectoris decreased significantly (P = 1.93 × 10 -7 )). The duration of angina tended to shorten, but there was no statistical difference (P = 0.09> 0.05). The number of angina attacks was significantly and positively correlated with the above serum indexes. Conclusion: Danhong injection can significantly reduce the risk of coronary atherosclerotic plaque rupture in patients with unstable angina pectoris, protect myocardial cells, and to some extent, ameliorate the vascular inflammatory reaction of coronary artery.