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炎性介质的过度释放是导致全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)的病理生理的关键因素之一。调控炎性基因表达一直是防治SIRS研究的核心环节,而转录水平的调控一直是基因表达的重点。近年来,随着对转录后水平调控机制的深入探究,转录后调控同样对基因的表达具有决定性的作用。m RNA降解调控作为转录后调控的重要部分,决定着基因表达的先后顺序、持续时间及蛋白产量。在转录后水平深入了解调控m RNA降解的机制,调控炎症反应过程中“抗炎”与“促炎”机制的平衡,为遏制炎症反应的恶性循环,预防和治疗过度炎症反应性疾病,如SIRS、急性肺损伤等开拓新思路。
Over-release of inflammatory mediators is one of the key factors that lead to the pathophysiology of systemic inflammatory response syndrome (SIRS). Regulation of inflammatory gene expression has always been the core link in the prevention and treatment of SIRS, and transcriptional regulation has been the focus of gene expression. In recent years, with the post-transcriptional level regulation mechanism in-depth study, post-transcriptional regulation of the same gene expression has a decisive role. Regulation of m RNA degradation as an important part of post-transcriptional regulation determines the order of gene expression, duration and protein yield. At the post-transcriptional level, we understand the mechanism of the regulation of m RNA degradation, regulate the balance between “anti-inflammatory” and “proinflammatory” mechanisms during the inflammatory response, and prevent and treat excessive inflammatory reactivity Diseases, such as SIRS, acute lung injury, open up new ideas.