2.2在药品开发领域的应用自20世纪60年代以来,人们越来越认识到口服吸收过程中药物在胃肠道溶出以及在肠壁上通透的重要性。近年来,许多用于建立BCS的研究已为新药开发尤其在药物通透性领域,提供了重要的定量数据。具体地说,BCS还在筛选候选药物进行全面开发、剂型选择、固体制剂溶出度试验体内外相关的可能性及预测并阐述与食物的相互作用等方面具有重要意义。 2.2 in the field of drug development Since the 1960s, people are increasingly aware of the absorption of drugs during oral absorption in the gastrointestinal tract and the importance of permeability in the intestinal wall. In recent years, many studies used to establish BCS have provided important quantitative data for new drug development, especially in the field of drug permeability. Specifically, BCS is also important in screening candidate drugs for full-scale development, the choice of dosage form, the likelihood of in vitro and in vivo dissolution testing of solid dosage forms, and predictions and elucidation of food-drug interactions.