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目的观察阿斯匹林对血小板与腺样囊性癌细胞（ＡＣＣ－Ｍ细胞）粘附能力的影响。方法采用体外实验观察测定不同条件下ＡＣＣ－Ｍ细胞的粘附率。结果加入富血小板血浆（ＰＲＰ）后ＡＣＣ－Ｍ细胞的粘附率明显提高（Ｐ＜０．００１）；ＰＲＰ先经阿斯匹林处理，再作用于ＡＣＣ－Ｍ细胞，则ＡＣＣ－Ｍ细胞的粘附性改变不显著（Ｐ＞０．０５）；阿斯匹林抑制血小板对ＡＣＣ－Ｍ细胞粘附性的影响在０．０１～０．２５ｇ／Ｌ浓度范围内呈非剂量依赖性。结论血小板能提高ＡＣＣ－Ｍ细胞粘附性，阿斯匹林对血小板促进ＡＣＣ－Ｍ细胞粘附性有明显抑制作用。
Objective To observe the effect of aspirin on the adhesion of platelets and adenoid cystic carcinoma cells (ACC-M cells). Methods The adhesion rate of ACC-M cells under different conditions was determined by in vitro experiments. Results The adhesion rate of ACC-M cells was significantly increased after platelet-rich plasma (PRP) was added (P<0.001); PRP was first treated with aspirin and then acted on ACC-M cells, then ACC-M cells The change of adhesion was not significant (P>0.05); the effect of aspirin on the adhesion of platelets to ACC-M cells was non-dose dependent in the range of 0.01-0.25 g/L. Conclusion Platelets can increase the adhesion of ACC-M cells, and aspirin can significantly inhibit the adhesion of platelets to ACC-M cells.