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目的:探讨氨茶碱对儿童咳嗽变异性哮喘患者的炎性指标和肺功能的影响。方法:选取64例儿童咳嗽变异性哮喘患者为研究对象,将所有患者根据随机数字表法分为对照组32例(常规治疗组)和观察组32例(常规治疗加氨茶碱组),对两组患儿治疗前和治疗后1周、2周的血清炎性指标、气道指标、肺功能指标进行检测。结果:治疗后1周和2周观察组的血清炎性指标、气道指标和肺功能指标改善幅度均大于对照组,且观察组治疗后2周检测指标改善幅度大于治疗后1周(P<0.05)。结论:氨茶碱可有效改善儿童咳嗽变异性哮喘患者的炎性状态,并可通过改善气道状态来达到改善肺功能的作用。
Objective: To investigate the effect of aminophylline on inflammatory parameters and pulmonary function in children with cough variant asthma. Methods: Sixty-four children with cough variant asthma were enrolled in this study. All patients were divided into control group (n = 32) and observation group (n = 32), routine treatment plus aminophylline group Two groups of children before treatment and after treatment for 1 week, 2 weeks of serum inflammatory markers, airway index, pulmonary function tests. Results: After 1 and 2 weeks of treatment, the serum inflammatory indexes, airway indexes and pulmonary function indexes in the observation group were all improved more than those in the control group, and the improvement of the detection indexes in the observation group two weeks after treatment was greater than that of the control group one week after treatment (P < 0.05). Conclusion: Aminophylline can effectively improve the inflammatory state in children with cough variant asthma, and can improve lung function by improving airway status.