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目的为了解围产期妇女HBV DNA定量检测特点。方法荧光定量PCR用于检测311例围产期妇女和同时期64例非围产期妇女及76例体检女性的HBV DNA。结果围产期妇女HBV DNA总阳性率(51.13%,159/311)低于同时期非围产期妇女(65.63%,42/64)(χ2=4.49,P=0.034)而与体检女性(40.79%,31/76)无差异(χ2=2.61,P=0.106),三组间小于检测下限阳性率无统计学差异(χ2=0.5996,P=0.4387;χ2=3.499,P=0.061);HBV DNA病毒载量在围产期妇女(5.16±2.14)、非围产期妇女(4.46±1.79)(t=1.778,P=0.0755)和体检妇女(4.78±2.17)(t=0.835,P=0.404)三组间无统计学差异。结论围产期妇女HBV感染率低于普通妇女,三组HBV DNA阳性妇女病毒载量具有相同的特征。
Objective To understand the characteristics of HBV DNA in perinatal women. Methods Fluorescent quantitative PCR was used to detect HBV DNA in 311 perinatal women, 64 non-perinatal women and 76 women in the same period. Results The total positive rate of HBV DNA in perinatal women (51.13%, 159/311) was lower than that in non-perinatal women (65.63%, 42/64) (χ2 = 4.49, P = 0.034) There was no significant difference between the three groups (χ2 = 0.5996, P = 0.4387; χ2 = 3.499, P = 0.061). There was no significant difference between the three groups (χ2 = 2.61, P = 0.106) The viral load in perinatal women (5.16 ± 2.14), non-perinatal women (4.46 ± 1.79) (t = 1.778, P = 0.0755) and the physical examination women (4.78 ± 2.17) No significant difference between the three groups. Conclusions The HBV infection rate of perinatal women is lower than that of normal women. The viral load of HBV DNA positive women in the three groups has the same characteristics.