借处理２－羟基－５－（２－苯基－４－喹啉基）－１，３，二唑同ＰＣｌ＿５／ＰＯＣｌ＿３之间的反应合成了２－氯－５－（２－苯基－４－喹啉基）－１，３，４－二唑（３）和通过２－基－５－（２－苯基－４－喹啉基）－１，３，４－二唑的甲基化，然后氧化制得２－甲磺酰基－５－（２－苯基－４－喹啉基）－１，３，４－二唑（６）．并分别研究了３和６同胺、叠氮及肼的反应，得到２，５－二取代的二唑新衍生物．初步观察了部分化合物的抗菌活性． Synthesis of 2-chloro-5- (2-phenyl-4 (2-phenyl-4-quinolinyl) -1,3-diazole with PCl_5 / POCl_3 Quinolinyl) -1,3,4-oxadiazole (3) and by methylation of 2-yl-5- (2-phenyl-4- quinolinyl) , Followed by oxidation to give 2-methanesulfonyl-5- (2-phenyl-4-quinolinyl) -1,3,4-oxadiazole (6). The reactions of 3 and 6 with amines, azides and hydrazines were studied respectively to give 2,5-disubstituted oxadiazole derivatives. The antibacterial activity of some compounds was preliminary observed.