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目的探讨急性脑梗死与炎症免疫因子基因表达的关系。方法测定128例脑梗死、65例对照组患者外周血进行白介素6(IL 6)、白介素10(IL 10)、肿瘤坏死因子α(TNFα)m RNA表达。结果脑梗死组IL 6、IL 10 m RNA表达水平与对照组比较差异有统计学意义(P<0.05),TNFα两组比较差异无统计学意义(P>0.05)。在脑梗死组未发现炎症免疫因子基因表达水平之间存在明显的相关性。结论炎症免疫因子参与脑梗死后急性反应,其外周血基因表达水平在脑梗死发病过程中具有重要作用。
Objective To investigate the relationship between acute cerebral infarction and inflammatory gene expression. Methods 128 cases of cerebral infarction and 65 cases of control group were assayed for interleukin 6 (IL 6), interleukin 10 (IL 10) and tumor necrosis factor α (TNFα) m RNA expression. Results The levels of IL - 6 and IL - 10 mRNA in cerebral infarction group were significantly different from those in control group (P <0.05). There was no significant difference between two groups (P> 0.05). No significant correlation was found between the levels of inflammatory and immune factors gene expression in cerebral infarction group. Conclusions Inflammatory and immune factors are involved in the acute response after cerebral infarction. The expression of peripheral blood gene plays an important role in the pathogenesis of cerebral infarction.