目的 :探讨不同性别对西布曲明片减肥疗效的影响。方法 :男、女性受试者各 2 2例 ,口服西布曲明 10mg·d- 1× 6wk。比较 2组治疗前后体重差百分比、腰围、臀围、腰围差值、臀围差值、腰臀围比(WHR)、BMI差值 ( BMI)及血糖、血脂等指标。结果 :女、男性组体重差百分比治疗后 2 ,4 ,6wk分别为 - 2 .1± 1.8,- 2 .9± 1.6,- 4.4± 2 .1,和 - 1.1± 0 .9,- 1.8± 1.1,- 2 .9± 1.4 (P <0 .0 5 ) ; BMI2 ,4 ,6wk女、男性组分别为 - 0 .7± 0 .6,- 0 .9±0 .5 ,- 1.4± 0 .7和 - 0 .35± 0 .2 8,- 0 .6± 0 .3,- 0 .9± 0 .5 ,P <0 .0 5 ;6wk女、男性组腰围分别为(87± 2 1)cm ,(98± 9)cm ,(P <0 .0 5 ) ;WHR、空腹血糖 6wk女性组较男性组均下降明显。结论 :女性组对西布曲明片减肥效果较男性组更为明显。 Objective: To investigate the effect of different genders on the efficacy of sibutramine in reducing weight. Methods: Male and female subjects, 22 cases each, sibutramine 10mg · d-1 × 6wk. Body weight difference, waist circumference, hip circumference, waist circumference difference, hip circumference difference, WHR, BMI, blood glucose, blood lipid and other indexes before and after treatment were compared between the two groups. RESULTS: At 2, 4 and 6 weeks post-treatment, the percent body weight differences between women and men were -2.1 ± 1.8,2.9 ± 1.6,4.4 ± 2.1 and -1.1 ± 0.9, -1.8 ± 1.1, -2.9 ± 1.4 (P <0.05). The BMI2, 4, 6wk female and male groups were -0.7 ± 0.6, -0.9 ± 0.5, -1.4 ± 0 .7 and -0.35 ± 0.28, -0.6 ± 0.3, -0.9 ± 0.5, P <0.05; 6wk, the waist circumference of the male group was (87 ± 2) 1) cm, (98 ± 9) cm, (P <0.05). WHR and fasting blood glucose in 6-week-old women were significantly lower than those in men. Conclusion: The effect of sibutramine on weight loss in female group is more obvious than that in male group.