Beam-column or beam-wall connections are an important problem in high-rise buildings. In this study, based on the analysis of an example structure, an analytical model for design of the semi-rigid connections between steel beams and RC walls in high-rise hybrid buildings is proposed. Also, the mechanical characteristics of these connections subjected to lowreversed cyclic loading are investigated through comparison of experimental results from three semi-rigid connections and two rigid connections. Moreover, some latent problems for design of these connections as well as the corresponding solutions are discussed. The results from the experiments and analyses indicate that semi-rigid connections exhibit satisfactory capacity and seismic performance, and the proposed design can be used in practice.