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TRAFs家族是一类多功能蛋白,最初是作为TNFR介导的信号通路中的转导分子而被发现的。TRAFs作为信号接头蛋白和调节分子,参与了TNFR、TLRs、NLRs和RLRs等多种受体介导的信号通路。TRAF7是最新发现的TRAF家族成员,因其保守的RING结构域,而具有E3泛素连接酶活性。此外,TRAF7还以其独特机制参与了MAP激酶、TNFR及TLR2介导的信号通路的转导,以及细胞应激、分化和凋亡等重要生理过程的调控,与乳腺癌、脑膜瘤等多种疾病的发生密切相关。结合最新研究进展对TRAF7的结构、功能及其参与的生物学过程进行综述。
The TRAFs family is a multi-functional protein originally discovered as a transduction molecule in TNFR-mediated signaling pathways. TRAFs, as signaling adapter proteins and regulators, are involved in many receptor-mediated signaling pathways such as TNFR, TLRs, NLRs and RLRs. TRAF7 is a recently discovered TRAF family member that has E3 ubiquitin ligase activity because of its conserved RING domain. In addition, TRAF7 also participates in the regulation of MAP kinase, TNFR and TLR2-mediated signal transduction and its important physiological processes such as cell stress, differentiation and apoptosis as well as breast cancer, meningiomas, etc. with its unique mechanism The occurrence of the disease is closely related. Combined with the latest research progress, the biological processes of TRAF7 are summarized.