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目的全面分析和研究新生儿化脓性脑膜炎在治疗前后脑脊液检查结果的变化分析。方法分别检测45例新生儿化脓性脑膜炎病患在治疗之前和治疗之后脑脊液中细胞数量、总蛋白数量、葡萄糖水平的变化情况,观察儿童病患在治疗过程中的临床疗效。结果所有新生儿病患中,治愈31例(68.9%),好转11例(24.4%),无效2例(4.4%),死亡1例(2.2%)。在治疗后期脑脊液细胞计数、压力与治疗之前进行比较有显著的降低,在研究对象中恢复正常的新生儿病患分别为34例(75.6%)和53例(88%)。在治疗后期总蛋白数量、葡萄糖水平和氯化物水平与治疗之前进行比较有显著的改善。结论抗生素药物的使用及相关治疗可有效改善新生儿化脓性脑膜炎病患的脑脊液细胞数量、压力水平、总蛋白水平、葡萄糖及氯化物水平。
Objective To analyze and study the changes of cerebrospinal fluid (CSF) examination before and after the treatment of neonatal purulent meningitis. Methods The changes of cell number, total protein and glucose in cerebrospinal fluid of 45 neonatal purulent meningitis patients before and after treatment were detected respectively. The clinical efficacy of children in treatment was observed. Results Among all neonatal patients, 31 (68.9%) were cured, 11 (24.4%) were improved, 2 (4.4%) were ineffective and 1 (2.2%) died. Cerebrospinal fluid cell counts and pressure were significantly reduced in the late treatment period compared with those before treatment, with 34 (75.6%) and 53 (88%) newborns returning to normal in the study population, respectively. There was a significant improvement in total protein amount, glucose level, and chloride level after treatment compared with before treatment. Conclusion The use of antibiotics and related treatment can effectively improve cerebrospinal fluid cell number, pressure, total protein, glucose and chloride levels in neonates with purulent meningitis.