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目的探讨洛阳地区一组Barrett’s食管(BE)的发病情况、内镜和病理学特点及其与幽门螺杆菌(H.pylori)感染的关系。方法采用普通胃镜检查结合病理检查结果,对洛阳地区有消化道症状的一组BE患者进行分析,同时采用尿素[14C]呼气试验药盒检查H.pylori感染对BE发病学的影响。结果2006年8月~2007年4月共有593例接受胃镜检查,有22例诊断为BE,BE发病率为3.71%;以短段、舌型发病率最高,分别占81.81%和77.27%;7例(31.8%)有典型反流症状;伴有低度异型性增生3例(13.64%),重度异型性增生1例(4.55%),并发腺癌1例(4.55%),其中伴有重度异型性增生的1例随访1年后并发腺癌;对其中的10例进行H.pylori检查,阳性率为90%。结论洛阳地区BE发病率较高,以短段、舌型为主,有典型反流症状者较少,伴有异型性增生、腺癌者及并发H.pylori感染者常见。
Objective To investigate the incidence, endoscopic and pathological features of a group of Barrett’s esophagus (BE) in Luoyang and its relationship with H. pylori infection. Methods A group of BE patients with gastrointestinal symptoms in Luoyang were analyzed by ordinary gastroscopy combined with pathological examination results. Meanwhile, the effect of H.pylori infection on the pathogenesis of BE was examined by urea [14C] breath test kit. Results A total of 593 patients underwent gastroscopy from August 2006 to April 2007, with 22 cases diagnosed as BE and BE with a prevalence of 3.71%. The incidence of short segment and tongue type was the highest, accounting for 81.81% and 77.27% respectively. 7 There were 3 cases (13.64%) with low-grade dysplasia, 1 case (4.55%) with severe atypical hyperplasia, and 1 case (4.55%) with adenocarcinoma accompanied by severe One case of atypical hyperplasia was followed up for 1 year and then developed adenocarcinoma. H.pylori was examined in 10 of them, the positive rate was 90%. Conclusions The incidence rate of BE in Luoyang area is high, mainly in short segment and tongue type, with less typical reflux symptoms, common with dysplasia, adenocarcinoma and H.pylori infection.