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Objective:To study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis(CAG)rats.Methods:Intervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa.Results:Mica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands.Especially,better effects were shown in the mid and high dose groups.Conclusion:Mica has the pharmacological action of protecting the gastric mucosa,promoting the regeneration of gastric glands,enhancing blood flow of the gastric mucosa,and consequently improving the inflammatory responses of the gastric mucosa.One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion(gastrin and somatostatin)by increasing the number of chief and parietal cells as well as G and D cells.