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DNA甲基化是表观遗传修饰的重要部分,基因异常甲基化在肿瘤发生、发展中扮演重要角色。众多研究结果表明单核苷酸多态性(single nucleotide polymorphism,SNP)与DNA甲基化之间存在密切联系,可能通过改变甲基化位点或对DNA甲基化相关酶类产生影响,继而影响到相关基因的甲基化状态,改变表达水平,导致肿瘤易感性发生变化。DNA甲基化代表的表观遗传与SNP代表的遗传突变能为癌变的分子机制研究提供更多的理论支持。
DNA methylation is an important part of epigenetic modification. Aberrant methylation plays an important role in tumorigenesis and development. Numerous studies have shown that there is a close relationship between single nucleotide polymorphism (SNP) and DNA methylation, possibly through changing the methylation site or influencing DNA methylation-related enzymes, and then Affect the methylation status of related genes, change the expression level, leading to changes in tumor susceptibility. The epigenetic representation of DNA methylation and the genetic mutation represented by SNP can provide more theoretical support for the molecular mechanism of carcinogenesis.