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尾加压素II(urotensinII,UII)最早是从鱼尾部下垂体中分离出的神经环肽 ,目前已从人体克隆出来 ,主要分布于神经和心血管组织 ,人体内一种孤立的G蛋白偶联受体GPR14是其特异性受体 ,主要分布于心血管和神经系统。当UII与GPR14结合后 ,引起细胞外Ca2 +内流 ,介导一系列生物学效应。在心血管系统 ,小剂量UII引起血流阻力轻度降低 ,心输出量轻度增加 ;大剂量引起心输出量明显减少 ,动脉血管强烈收缩 ,其缩血管效应是内皮素 1的 10余倍 ,是迄今所知最强的缩血管活性肽。
Urotensin II (UII), the earliest neuropeptide peptide isolated from the pituitary gland of human fish, has been cloned from human and mainly distributed in nerve and cardiovascular tissues. An isolated G protein double Co-receptor GPR14 is its specific receptor, mainly in the cardiovascular and nervous system. When UII and GPR14 combined, causing extracellular Ca2 influx, mediated a series of biological effects. In the cardiovascular system, a small dose of UII caused a slight decrease in blood flow resistance, a slight increase in cardiac output; cardiac output was significantly reduced due to high doses, arterial vasoconstriction was strong, and its vasoconstrictor effect was more than 10 times that of endothelin 1 The strongest vasoactive peptide known to date.