获得性血友病的病因是因体内产生中和Ⅷ因子的抗体(抗-Ⅷ抗体),临床表现与先天性出血性疾病相似,如自发性出血(尤其关节腔和肌肉)、瘀斑、甚至轻微外伤或手术后出血不止。典型患者见于老人及妇女。虽发病的形式各有不同,但通常伴有“自身免疫”或过敏成份,包括类风湿性关节炎和其它胶原性血管病、肿瘤、天疱疮、溃疡性结肠炎及哮喘;年 Acquired hemophilia is caused by an antibody that neutralizes factor Ⅷ (anti-Ⅷ) in the body and has clinical manifestations similar to those of congenital hemorrhagic disease such as spontaneous bleeding (especially in the articular cavities and muscles), ecchymosis, and even Minor trauma or bleeding after surgery. Typical patients found in the elderly and women. Although the form of the disease varies, it is often accompanied by “autoimmune” or allergic components, including rheumatoid arthritis and other collagen-derived vascular diseases, tumors, pemphigus, ulcerative colitis, and asthma;