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目的探讨银杏叶提取物对慢性阻塞性肺疾病急性加重期(AECOPD)患者血管内皮功能的影响。方法将60例AECOPD患者随机分为常规治疗组(CT组),银杏叶组(GBLE组),每组30例;并选择同期30例健康体检者作为对照组。两组常规治疗相同,GBLE组每日加用舒血宁注射液20 mL静脉滴注,连用2周。酶联免疫吸附法检测血清一氧化氮(NO)、血栓调节蛋白(TM)和血管假血友病因子(vWF)。结果两个治疗组治疗前NO,TM显著低于对照组(P<0.01),vWF显著高于对照组(P<0.01)。治疗后,两组NO,TM水平较治疗前显著升高(P<0.01),而GBLE组升高更为显著,与CT组比较有统计学差异(P<0.01);两组vWF水平较治疗前显著下降(P<0.01),GBLE组下降较CT组更为显著(P<0.01)。结论银杏叶提取物有显著改善AECOPD患者血管内皮细胞功能的作用,可预防血栓性疾病。
Objective To investigate the effect of Ginkgo biloba extract on vascular endothelial function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD were randomly divided into conventional treatment group (CT group) and Ginkgo biloba group (GBLE group), 30 cases in each group. 30 healthy subjects were selected as the control group. Two groups of conventional treatment the same, GBLE group daily with Shuxuening injection 20 mL intravenous infusion, once every 2 weeks. Serum nitric oxide (NO), thrombomodulin (TM) and von Willebrand factor (vWF) were detected by enzyme-linked immunosorbent assay. Results Before treatment, NO and TM in two treatment groups were significantly lower than those in control group (P <0.01), and vWF was significantly higher than that in control group (P <0.01). After treatment, NO and TM levels in both groups were significantly higher than those before treatment (P <0.01), while those in GBLE group were significantly higher than those in CT group (P <0.01). The vWF levels in both groups were significantly higher than those before treatment (P <0.01). The decrease in GBLE group was more significant than that in CT group (P <0.01). Conclusion Ginkgo biloba extract can significantly improve the function of vascular endothelial cells in AECOPD patients and prevent thrombotic diseases.