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妊娠肝内胆汁淤积症(ICP)是一种可引起胎儿不良结局的妊娠并发症,其发病机制在进一步研究中。许多研究认为ICP患者胎盘功能的改变与胎儿不良结局密切相关。本文从雌激素水平和雌激素受体,胎盘血管舒缩因子的失衡,血管内皮生长因子和表皮生长因子受体表达,免疫因素等方面在胎盘功能改变中起的作用进行综述。
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related complication that can cause adverse outcomes in the fetus, and its pathogenesis is under further investigation. Many studies suggest that changes in placental function in ICP patients are closely related to adverse fetal outcomes. This article reviews the role of estrogen in estrogen receptor, placental vasoconstriction factor imbalance, expression of vascular endothelial growth factor and epidermal growth factor receptor, immune factors in the changes of placental function.