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目的检测慢性阻塞性肺疾病(COPD)患者血清细胞因子IL-6、IL-8,TNF-α,观察N-乙酰半胱氨酸对其影响。方法40例COPD急性发作期患者分为两组,治疗组:服用N-乙酰半胱氨酸(1次200mg,3次/d),并给予抗炎、对症治疗;对照组:予抗炎、对症治疗;另设正常组。放射免疫法进行检测。结果COPD急性发作期患者血清细胞因子IL-6、IL-8,TNF-α水平升高,治疗后有所下降,但仍高于正常组。治疗组与对照组治疗前后比较差异无统计学意义。结论N-乙酰半胱氨酸短期治疗对COPD患者血清细胞因子IL-6、IL-8,TNF-α无明显影响。
Objective To detect serum cytokines IL-6, IL-8 and TNF-α in patients with chronic obstructive pulmonary disease (COPD) and observe the effect of N-acetylcysteine. Methods Forty patients with acute exacerbation of COPD were divided into two groups. The treatment group was given N-acetylcysteine (200mg once a day, once a day) and given anti-inflammatory and symptomatic treatment. The control group was given anti-inflammatory, Symptomatic treatment; another set of normal group. Radioimmunoassay. Results The levels of serum cytokines IL-6, IL-8 and TNF-α in patients with acute exacerbation of COPD increased but decreased after treatment, but were still higher than those in normal subjects. There was no significant difference between the treatment group and the control group before and after treatment. Conclusion N-acetyl cysteine short-term treatment of COPD patients with serum cytokines IL-6, IL-8, TNF-α no significant effect.