【摘 要】
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To the Editor: Diabetic nephropathy (DN) is the leading cause of chronic renal diseases and accounts for almost 50％ of all end?stage renal diseases worldwide. Th
【机 构】
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National Clinical Research Center of Kidney Diseases, Research Institute of Nephrology, Jinling Hosp
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To the Editor: Diabetic nephropathy (DN) is the leading cause of chronic renal diseases and accounts for almost 50％ of all end?stage renal diseases worldwide. The prevalence of DN increased significantly after 2010 in China.[1,2] DN is clinically characterized by proteinuria and morphological and ultrastructural changes in the kidney. The pathogenesis of DN is multifactorial and extremely complex, including hyperglycemia, transforming growth factor (TGF)?β1, angiotensin II, DNA methylation, chromatin histone modification, microRNAs, and long noncoding RNAs.
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