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目的:观察不同体质母亲母乳喂养与婴幼儿患呼吸道合胞病毒(RSV)毛细支气管炎的相关性。方法:检测过敏体质母亲初乳细胞因子TGF-β1、IL-10、IL-4水平,同时追踪其喂养儿RSV毛支患病率,并检测RSV毛支患儿外周血细胞因子TGF-β1、IL-10、IL-4水平,同期收集非过敏体质母亲初乳及其母乳喂养儿外周血作对照。结果:过敏体质母亲初乳细胞因子TGF-β1水平显著低于非过敏体质母亲初乳(P<0.05),IL-4水平则显著高于非过敏体质母亲初乳(P<0.05),IL-10水平在两者之间无统计学差异(P>0.05);过敏体质母亲母乳喂养儿RSV毛支患病率显著高于非过敏体质母亲母乳喂养儿(P<0.05);过敏体质母亲母乳喂养的RSV毛支患儿外周血细胞因子TGF-β1、IL-10水平显著低于非过敏体质母亲母乳喂养的RSV毛支患儿(P<0.05),而IL-4水平则显著高于非过敏体质母亲母乳喂养的RSV毛支患儿(P<0.05)。结论:过敏体质母亲母乳喂养可能会导致喂养儿易患RSV毛支。
Objective: To observe the correlation between breastfeeding and respiratory syncytial virus (RSV) bronchiolitis in different constitutional mothers. Methods: The levels of TGF-β1, IL-10 and IL-4 in the colostrums of allergic mothers were detected, and the prevalence of bronchial branches of RSV was tracked. The levels of TGF-β1, IL- -10, IL-4 levels, the same period collection of non-allergic mother’s colostrum and breastfeeding children as control. Results: The level of TGF-β1 in colostrum of allergic mothers was significantly lower than that in non-allergic mothers (P <0.05), while the level of IL-4 was significantly higher than that of non-allergic mothers (P <0.05) (P> 0.05). The prevalence of WBC of RSV in breastfeeding children with allergy was significantly higher than that of non-allergic mothers (P <0.05), breastfeeding of allergic mother (P <0.05), but the level of IL-4 was significantly higher in children with RSV bronchiolitis than in non-allergic mother breastfeeding children with RSV bronchiolitis Breastfeeding RSV patients with breastfeeding children (P <0.05). CONCLUSIONS: Breastfeeding of allergic mothers may result in feeding susceptible RSV hair follicles.