论文部分内容阅读
目的观察普伐他汀对高血压伴左室肥厚舒张功能不全的疗效。方法选择高血压伴左室肥厚舒张功能不全的患者86例,随机分成普伐他汀组和对照组,每组43例,普伐他汀组在标准降压的基础上加用普伐他汀20 mg,每天1次。观察治疗前后心脏结构和舒张功能的变化。结果治疗6个月后,在普伐他汀组中,室间隔舒张末期厚度(IVSD)、左室后壁舒张末期厚度(LVPWD)明显变薄,E峰与A峰的比值(E/A)明显升高(P<0.05)。与对照组比较,IVSD、LVPWD明显变薄,E/A明显升高(P<0.05)。结论普伐他汀能有效减轻左心室肥厚,明显改善舒张功能。
Objective To observe the effect of pravastatin on left ventricular hypertrophy and diastolic dysfunction in hypertensive patients. Methods Eighty-six patients with hypertension and diastolic dysfunction of left ventricular hypertrophy were randomly divided into pravastatin group and control group, with 43 cases in each group. Pravastatin group was given pravastatin 20 mg on the basis of standard antihypertensive treatment, 1 day. Changes of cardiac structure and diastolic function before and after treatment were observed. Results After 6 months of treatment, the mean left ventricular end-diastolic thickness (IVSD) and left ventricular end-diastolic thickness (LVPWD) in the pravastatin group were significantly reduced, and the E / A ratio (E / A) Increased (P <0.05). Compared with the control group, IVSD and LVPWD decreased significantly and E / A increased significantly (P <0.05). Conclusion Pravastatin can effectively reduce left ventricular hypertrophy and improve diastolic function.