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目的:调查湖北地区药瘾者HGV感染状况。方法:检查药瘾者的血清HGV感染指标,抗HGV和HGV-RNA分别用ELISA和RT-PCR法检测。结果:375例药瘾者HGV的感染率31.47％(118例)。静脉药瘾者HGV-RNA阳性率32.92％,口服药瘾者为27.96％,两者比较有显著差异(x~2=4.36,P<0.05);女性药瘾者HGV-RNA阳性率(32.84％)高于男性药瘾者(13.46％,X~2=11.55,P<0.01);成瘾时间大于2年者的HGV-RNA阳性率(52.76％),显著高于成瘾时间小于2年者(9.66％,X~2=79.06,P<0.01)。所有HGV感染者的肝功能正常。结论:药瘾者具有较高的HGV感染率。
Objective: To investigate the status of HGV infection among drug addicts in Hubei Province. Methods: The indexes of serum HGV infection in drug addicts were examined. Anti-HGV and HGV-RNA were detected by ELISA and RT-PCR respectively. Results: The infection rate of HGV in 375 drug addicts was 31.47% (118 cases). The positive rate of HGV-RNA was 32.92% in intravenous drug users and 27.96% in oral drug users, with a significant difference (x ~ 2 = 4.36, P <0.05) ) Was higher than male drug addicts (13.46%, X ~ 2 = 11.55, P <0.01). The positive rate of HGV-RNA in patients who had been addicted to for more than 2 years (52.76%) was significantly higher than that of addicts (9.66%, X ~ 2 = 79.06, P <0.01). All HGV infected people had normal liver function. Conclusion: Drug addicts have a high HGV infection rate.