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目的探讨新疆地区维吾尔族人群非酒精性脂肪性肝病(NAFLD)的相关危险因素。方法收集新疆医科大学第一附属医院新入院维吾尔族患者及新疆医科大学体检中心维吾尔族健康体检者共966例,进行问卷调查及血生化和B超检查,依据体检情况分为NAFLD组(569例)和非NAFLD组(397例);按照体质量指数(BMI)和腰围身高比值(WHtR)分层对NAFLD组进行危险因素的相关性分析。结果两组对象BMI、WHtR比较,差异有统计学意义(P<0.05);超重(OR=2.527,P<0.05)和肥胖(OR=1.938,P<0.05)是NAFLD的危险因素。多因素Logistic回归分析显示:BMI、空腹血糖(FPG)和三酰甘油(TG)与NAFLD有关(P<0.05),是NAFLD的危险因素。结论BMI、WHtR、FPG和TG是NAFLD的危险因素,在评价和预测NAFLD的高危人群中具有一定的临床意义。
Objective To explore the related risk factors of non-alcoholic fatty liver disease (NAFLD) in Uighur population in Xinjiang. Methods A total of 966 Uygur patients admitted to the First Affiliated Hospital of Xinjiang Medical University and the Uygur physical examination center of Xinjiang Medical University Medical Center were investigated. Questionnaires and blood biochemical tests and B-ultrasound were performed. According to the physical examination, they were divided into NAFLD group (569 cases ) And non-NAFLD group (397 cases). The correlation analysis of risk factors in NAFLD group according to body mass index (BMI) and waist circumference height ratio (WHtR) stratified. Results The BMI and WHtR of the two groups were significantly different (P <0.05). Overweight (OR = 2.527, P <0.05) and obesity (OR = 1.938, P <0.05) were the risk factors for NAFLD. Multivariate Logistic regression analysis showed that BMI, fasting blood glucose (FPG) and triglyceride (TG) were associated with NAFLD (P <0.05), which were risk factors for NAFLD. Conclusions BMI, WHtR, FPG and TG are risk factors of NAFLD, and have certain clinical significance in evaluating and predicting high-risk population of NAFLD.