动物模型在肝病学的发展中起重要作用。近几年,在了解特异基因功能、代谢通路和疾病进程方面,啮齿类动物模型发挥了巨大作用。人鼠嵌合肝是利用人肝细胞异种移植到受体鼠肝内建立的新型动物模型。受体鼠可分为免疫缺陷小鼠或诱导免疫耐受大鼠,两者均能初步建立 Animal models play an important role in the development of hepatology. In recent years, rodent models have played a significant role in understanding specific gene functions, metabolic pathways and disease progression. Human chimeric liver is a novel animal model established by xenotransplating human hepatocytes into the recipient rat liver. Recipient rats can be divided into immunodeficient mice or induced immune tolerance rats, both of which can be initially established