目的：通过测定妊娠、哺乳期妇女血清钙磷、游离钙、碱性磷酸酶等生化指标观察妊娠哺乳期妇女骨代谢的变化。方法：测定３０ 例孕妇产前及产后不同时间血清钙磷、游离钙、碱性磷酸酶等生化指标，以未妊娠健康妇女２０ 例相对照。结果：妊娠和哺乳期妇女血清总钙与非妊娠健康妇女相比无明显统计学差异，但血清游离钙和磷的浓度较对照组降低（Ｐ＜ ０．０１），碱性磷酸酶活性明显升高（Ｐ＜ ０，０５）。结论：妊娠、哺乳期妇女排钙增加时主要动用骨钙以维持血钙平衡。观察妊娠和哺乳期妇女血液中钙、磷等生化指标的变化，对指导妊娠和哺乳期妇女的保健以及合理膳食是必要的 OBJECTIVE: To observe the changes of bone metabolism in pregnant and lactating women by measuring the serum calcium, phosphorus, free calcium and alkaline phosphatase in pregnancy and breastfeeding women. Methods: The serum and serum calcium, phosphorus, alkaline phosphatase and other biochemical indexes of 30 pregnant women at different time of prenatal and postnatal period were determined. 20 healthy women without pregnancy were compared with each other. Results: Serum total calcium in pregnant and lactating women had no statistical difference compared with non-pregnant healthy women, but serum free calcium and phosphorus concentrations were lower than those in control group (P <0.01), alkaline phosphatase activity was significantly increased High (P <0,05). Conclusion: Pregnant and lactating women mainly use calcium to maintain the balance of calcium when they increase. Observing changes in biochemical markers such as calcium and phosphorus in the blood of pregnant and lactating women is essential for the care and reasonable diet of pregnant and lactating women