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目的：探讨总前列腺特异性抗原（TPSA）与游离前列腺特异性抗原（FPSA）的比值（F／TPSA）在TPSA4～10μg／L之间的良性前列腺增生（BPH）和前列腺癌（PC）中鉴别诊断的意义。方法：采用放免法对281例病人的TPSA和FPSA进行测定，并计算F／TPSA，其中TPSA在4～10μg／L的PC和BPH病人分别是10例和51例。结果：PC组和BPH组的TPSA分别是6．22μg／L和6．04μg／L，两组相比差异不显著（P＞0．05）；而F／TPSA比值分别是0．11和0．21，两组相比差异显著（P〈0．01）。当F／TPSA为0．15～0．20时，诊断的敏感性和特异性分别是70％～90％和88％～67％。结论：F／TPSA有助于鉴别TPSA在4～10μg／L之间的BPH和PC，具有较高的敏感性和特异性，可以减少不必要的活检，是一种较好的鉴别BPH和PC的方法。
Objective: To investigate the ratio of total prostate specific antigen (TPSA) to free prostate specific antigen (FPSA) in differential diagnosis of benign prostatic hyperplasia (BPH) and prostate cancer (PC) between TPSA 4 ~ 10μg / L Diagnostic significance. Methods: TPSA and FPSA in 281 patients were determined by radioimmunoassay and F / TPSA was calculated. Among them, 10 and 51 cases of PC and BPH patients with TPSA ranging from 4 to 10 μg / L, respectively. Results: The TPSA of PC group and BPH group were 6.22μg / L and 6.04μg / L, respectively, and there was no significant difference between the two groups (P> 0.05). The F / TPSA ratios were 0.11 and 0 .21, there was significant difference between the two groups (P <0.01). The diagnostic sensitivity and specificity were 70% -90% and 88% -67%, respectively, when F / TPSA was 0.15-0.20. Conclusion: F / TPSA can help identify BPH and PC with TPSA between 4 and 10 μg / L, which has high sensitivity and specificity and can reduce unnecessary biopsy. It is a better method to identify BPH and PC Methods.