先锋霉素在治疗细菌性脑膜炎中不被认为是盲选药物,因该药进入脑脊液浓度低。cefotaxime(HR756)是一种新的先锋霉素,对细菌性脑膜炎有强力的抗菌作用。在志愿者中研究cefotaxime的肾脏耐受性,以丙氨酸—氨基肽酶排泄作为指标,肾功能是好的,无cefotaxime增加氨基糖甙的肾毒性的证据。Karimi等指出,健康成人志愿者Cefotoxmne 2g静脉注射,脑脊液浓度仅为35～161μg/L,但此低浓度即可抑制脑膜炎的大多数致病菌,且当脑膜炎症时进入脑脊液的浓度可能更高些。Shah等对4例急性细菌性脑膜炎给予Cefotaxime治疗,用微生物学方法和高压液体色谱法测定脑脊液值,平均为0.3～12.5mg/L。本文报导14例由于流感杆菌、β溶血性链球菌、肺炎链球菌、葡萄球菌、脑膜炎球菌、大肠杆菌或绿脓 Vanguard ADM is not considered a blind drug in the treatment of bacterial meningitis because of its low cerebrospinal fluid concentration. Cefotaxime (HR756) is a new cephalosporin that has a strong antibacterial effect against bacterial meningitis. Studying renal tolerance of cefotaxime in volunteers, alanine-aminopeptidase excretion as an indicator, renal function was good, and no evidence of increased cephalotaxime nephrotoxicity with cefotaxime. Karimi et al. Pointed out that healthy adult volunteers Cefotoxmne 2g intravenous injection of cerebrospinal fluid concentration of only 35 ~ 161μg / L, but this low concentration can inhibit most of meningitis pathogens, and into the cerebrospinal fluid concentration may be more Higher. Shah and other 4 cases of acute bacterial meningitis given Cefotaxime treatment, using microbiological methods and high pressure liquid chromatography determination of cerebrospinal fluid values, with an average of 0.3 ~ 12.5mg / L. This article reports 14 cases due to influenza bacilli, β hemolytic streptococcus, Streptococcus pneumoniae, Staphylococcus, meningococcus, Escherichia coli or pus