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正常的妊娠维持为母体对胎儿的免疫耐受。HLA-G作为一种人类的主要组织相容性复合体,具有限多态性。HLA-G多态性与胚胎的早期发育、IVF妊娠结局、正常妊娠维持、多种妊娠相关疾病及妊娠并发症(如复发性流产、子痫前期)的发生发展密切相关。
Normal pregnancy to maintain the mother’s immune tolerance to the fetus. HLA-G is a human major histocompatibility complex with limited polymorphism. HLA-G polymorphisms are closely related to the early development of embryos, IVF pregnancy outcomes, normal pregnancy maintenance, multiple pregnancy-related diseases and pregnancy complications (such as recurrent spontaneous abortion and preeclampsia).