目的研究金银花水提取物作为微生态调节剂对肠道微生态失调大鼠肠道菌群的调整作用。方法结扎大鼠胆总管造成肠道菌群失调模型后分别以金银花、丽珠肠乐、金银花与丽珠肠乐合剂、生理盐水灌胃,于灌胃4d后测定各组大鼠肠道菌群组分、乙酸含量及肝脏中肠杆菌易位情况。结果大鼠肠道菌群失调得到恢复,肠道内乙酸含量增加,易位至肝脏的肠杆菌数量减少,与自然恢复组相比,差异有统计学意义(P<0.05),金银花与丽珠肠乐合剂组效果最佳。结论金银花水提物作为益生元对大鼠肠道菌群失调具有调整作用。 Objective To study the regulation effect of water extract of honeysuckle (Honeysuckle) as microecological regulator on gut microflora in rats with gut microflora disorders. Methods Ligustrum, Ligustrum, Honeysuckle and Lizhu Changle mixture and normal saline were intragastrically administrated after the ligation of the common bile duct of rats with intestinal flora. After 4 days of intragastric administration, the gut flora Components, acetic acid content and liver E. coli translocation situation. Results The imbalance of intestinal flora was restored in rats, the content of acetic acid in the intestine increased and the number of enterobacteria translocated to the liver decreased. Compared with the natural recovery group, the difference was statistically significant (P <0.05) Le mixture of the best. Conclusion Honeysuckle water extract as a prebiotics can regulate the imbalance of intestinal microflora in rats.