论文部分内容阅读
糖尿病心肌病是除外冠状动脉疾病或高血压等糖尿病继发性损害之外独立存在的特异性心肌损害,是糖尿病患者发展为心力衰竭的重要原因之一。衰老和代谢异常之间的关系密切,而研究证实沉默信息调节因子蛋白家族可通过去乙酰化作用调节寿命及代谢。现主要以沉默信息调节因子蛋白家族、衰老及糖尿病心肌病三者之间关系的研究进展展开本综述,以进一步阐明糖尿病心肌病的发病机制及沉默信息调节因子基因作为治疗靶点的潜能。
Diabetic cardiomyopathy is an independent myocardial damage independent of secondary damage to diabetes, such as coronary artery disease or hypertension, and is one of the important causes for the development of heart failure in diabetic patients. Senescence and metabolic abnormalities are closely related, but studies have shown that the SIR protein family regulates longevity and metabolism through deacetylation. This review focuses on the research progress of the relationship between the SIR protein family, aging and diabetic cardiomyopathy in order to further elucidate the pathogenesis of diabetic cardiomyopathy and the potential of SIR genes as therapeutic targets.