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生殖生物学的一个重要问题是着床前母体是否识别妊娠。澳大利亚O’Neill等发现,妊娠和假孕小鼠在交配后第一周内脾重增加,前者在第四天出现,后者则在第二天出现。与妊娠时脾重增加延缓相应的是脾脏血小板池显著减少。妊娠小鼠在交配当天的10∶30外周血液血小板计数显著减少,持续至第七天,再恢复正常,这可称为早孕相关性血小板减少。而假孕小鼠无此反应。血小板减少与受精卵的存在有关。双侧输卵管结扎的小鼠与有生育能力的雄鼠交配后亦无此反应。受精卵移植至假孕小鼠后,3小时内即出现血小板减少,反应程度与移植胚胎数显著相关。因此,小鼠对妊娠的最初全身性反应为机体对血液血小板的需要增加,导致脾脏和外周血液血小板浓度显著减少。
An important issue in reproductive biology is whether prenatal maternal identification of pregnancy. In Australia, O’Neill et al found that in pregnant and pseudopregnant mice, spleen mass increased in the first week after mating, with the former appearing on the fourth day and the second on the second day. Corresponding to the increase of spleen weight during pregnancy, the spleen platelet pool was significantly reduced. Pregnant mice at 10:30 maternal day peripheral blood platelet count significantly decreased until the seventh day and returned to normal, which may be referred to as early pregnancy-related thrombocytopenia. The pregnant mice did not respond. Thrombocytopenia and the presence of fertilized eggs. Bilateral tubal ligation of mice and fertility of male mice did not respond after mating. After transplanted into pseudopregnant mice, thrombocytopenia occurred within 3 hours and the degree of reaction was significantly correlated with the number of embryos transferred. Thus, the initial systemic reaction of a mouse to pregnancy is an increase in the need for blood platelets in the body, resulting in a significant reduction in platelet concentrations in the spleen and peripheral blood.