女性泌乳素瘤(PRL 瘤)的发生率远远高于男性,这是否与雌激素有关尚无定论。本文报道了1例雌激素诱发的男性 PRL 瘤。病例患者男性,26岁。发育正常,具有正常的男性性征,染色体核型为46,xy。患者因患有易性癖(transsexulism)而接受雌激素治疗。治疗前先后查了两次血浆睾丸酮、雌二醇、FSH、LH 及 PRL 水平均正常,最初用乙炔雌二醇100μg/d 和醋酸氯甲孕酮 The incidence of female prolactinomas (PRL tumors) is much higher than that of males, and it is inconclusive whether estrogen is involved. This article reports a case of estrogen-induced male PRL tumor. Case patient male, 26 years old. Normal development, with normal male sexual characteristics, chromosome karyotype 46, xy. Patients receive estrogen because of transsexulism. Checked twice before treatment, plasma testosterone, estradiol, FSH, LH and PRL levels were normal, initially with ethinyl estradiol 100μg / d and chlorpromazine acetate