应用免疫组化、荧光免疫、放射免疫、RT-PCR、ECT、动物实验等现代技术对肾综合征出血热(HFRS)发病机制作了系列研究,发现HFRS病毒(HFRSV)有直接致病作用,病毒之膜蛋白(MP)在发病中起关键作用。HFRSV能侵犯外周血单个核细胞(PBMC),在其中复制,表达其结构蛋白,并随单核细胞散布至其它组织;病毒MP可引起肾小管上皮细胞融合;PBMC中病毒MP之表达强度与血浆内皮素水平 A series of studies on the pathogenesis of hemorrhagic fever with renal syndrome (HFRS) using modern techniques such as immunohistochemistry, fluorescence immunoassay, radioimmunoassay, RT-PCR, ECT and animal experiments found that HFRSV has a direct pathogenicity, The viral membrane protein (MP) plays a key role in the pathogenesis. HFRSV can invade peripheral blood mononuclear cells (PBMCs), in which replication and expression of its structural protein, and with mononuclear cells spread to other tissues; virus MP can cause renal tubular epithelial cells fusion; PBMC virus MP expression intensity and plasma Endothelin levels