青光眼的视网膜神经纤维层缺损及视盘参数改变

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青龙眼的主要病理过程是视网膜神经纤维及视乳头盘沿的丢失。青光眼的视网膜神经纤维层缺损可分为局部缺损和弥漫缺损,这两作缺损的存在可能预示着存在两种或多种造成青光眼视神经损害的机制。本文总结分析了75例开角型青光眼及慢性闭角型青光眼病人131只眼的彩色立体眼底象.根据视网膜神经纤维层损害形态的不同,将131只限分为局限性RNFLD;弥漫性RNFLD;混合性RNFLD三组。对各组眼的视盘参数进行定最测量并参照Airaksinen法对视网膜神经纤维层进行半定量评估,根据视杯扩大的形态及盘沿面积的大小将各组中的病眼分为0、Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ几个阶段,采用SYSTAT统计软件对三组病人的c/D、沿盘面积比进行对比分析;且对各级RNFLD的半定量值与盘沿面积进行直线相关及回归分析。结果表明三组间的C/D及沿盘面积比存在着相当显著性差异(P=0.000),且局部缺损组主要处于青光眼的早期和中期,混合缺损组主要分布于中期,弥漫缺损组主要分布于中晚期。视网膜神经纤维层缺损的半定量值与盘沿面积低度相关。青光眼视网膜纤维层缺损的不同形态表现,不同缺损形态组的视盘参数的差异及视杯扩大形式的差异,可能预示着存在多种造成青光眼视神经损害的机制。 The main pathological process of the Dragon Eye is the loss of retinal nerve fibers and optic disc rim. Glaucoma retinal nerve fiber layer defects can be divided into local defects and diffuse defects, the presence of these two defects may indicate the existence of two or more mechanisms that cause glaucomatous optic nerve damage. This article summarizes the color stereoscopic fundus images of 131 eyes of 75 patients with open-angle glaucoma and chronic angle-closure glaucoma. According to the morphological changes of retinal nerve fiber layer, 131 were divided into limited RNFLD; diffuse RNFLD; mixed RNFLD three groups. According to the Airaksinen method, retinal nerve fiber layer was semi-quantitatively evaluated. According to the enlargement of the optic cup and the size of the disc area, the affected eyes in each group were divided into 0, Ⅱ, Ⅲ, Ⅳ, Ⅴ in several stages, using SYSTAT statistical software for three groups of patients c / D, along the disk area ratio comparative analysis; and semi-quantitative RNFLD at all levels and the disk area linear correlation and regression analysis. The results showed that there was a significant difference (P = 0.000) between the three groups in C / D and along the disc area, and the local defect group was mainly in the early and middle stage of glaucoma. The mixed defect group mainly distributed in the mid- Group mainly in the late. Semi-quantitative values ​​of retinal nerve fiber layer defects correlate with low disc-area. The different morphological features of retinal fiber layer defect in glaucoma, the difference of optic disc parameters and the enlarged form of optic cup in different defect morphological groups may indicate that there are many mechanisms that cause optic nerve damage in glaucoma.
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